Phospholamban

PLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PLP, 1ZLL, 2HYN
Identifiers
Aliases	PLN, CMD1P, CMH18, PLB, phospholamban
External IDs	OMIM: 172405; MGI: 97622; HomoloGene: 136758; GeneCards: PLN; OMA:PLN - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	118,561,716 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	53,222,083 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; vena cava; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; tail of epididymis; ; triceps brachii muscle;
	Top expressed in
	interventricular septum; ; right ventricle; ; cardiac muscles; ; myocardium of ventricle; ; atrioventricular valve; ; left ventricle; ; aortic valve; ; endocardial cushion; ; atrium; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; ATPase binding; calcium channel regulator activity; protein binding; ATPase inhibitor activity; identical protein binding; protein homodimerization activity;
Cellular component	integral component of membrane; vesicle; endoplasmic reticulum membrane; membrane; mitochondrial membranes; sarcoplasmic reticulum; endoplasmic reticulum; mitochondrion; sarcoplasmic reticulum membrane; perinuclear region of cytoplasm; calcium ion-transporting ATPase complex; protein-containing complex;
Biological process	Notch signaling pathway; regulation of ryanodine-sensitive calcium-release channel activity; negative regulation of calcium ion binding; regulation of cardiac conduction; regulation of calcium ion transport; negative regulation of catalytic activity; regulation of heart contraction; regulation of cytosolic calcium ion concentration; cardiac muscle tissue development; negative regulation of heart contraction; response to testosterone; regulation of the force of heart contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; negative regulation of ATP-dependent activity; regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of calcium ion import; response to zinc ion; cellular calcium ion homeostasis; regulation of relaxation of cardiac muscle; negative regulation of calcium ion transmembrane transporter activity; blood circulation; negative regulation of heart rate; negative regulation of calcium ion import; response to insulin; regulation of cardiac muscle cell contraction; negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of calcium ion transport; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; regulation of cardiac muscle cell membrane potential; regulation of the force of heart contraction by cardiac conduction; regulation of relaxation of muscle; negative regulation of calcium ion import into sarcoplasmic reticulum; protein homooligomerization; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; relaxation of cardiac muscle; calcium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	5350
	18821
	ENSG00000198523
	ENSMUSG00000038583
	P26678
	P61014
	NM_002667
	NM_001141927; NM_023129
	NP_002658
	NP_001135399; NP_075618
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
PDB	IPR005984 PF04272 (ECOD; PDBsum)
AlphaFold	IPR005984; PF04272;

	Phospholamban pentamer
Identifiers
Symbol	Phospholamban
Pfam	PF04272
InterPro	IPR005984
SCOP2	1fjk / SCOPe / SUPFAM
TCDB	1.A.50
OPM superfamily	62
OPM protein	1zll
Membranome	383
PDB
Available protein structures:
PDB	IPR005984 PF04272 (ECOD; PDBsum)
AlphaFold	IPR005984; PF04272;

Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca²⁺) pump in cardiac muscle cells.