Phosphoglycerate dehydrogenase
| phosphoglycerate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.95 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Phosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyzes two individual chemical reactions.
In the first reaction, the two substrates are 3-phosphoglyceric acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are phosphohydroxypyruvic acid (i.e. 3-phosphonooxypyruvic acid), reduced NADH, and a proton. This enzyme can also catalyse the interconversion of α-hydroxyglutaric acid and α-ketoglutaric acid using the same cofactors.
As of 2012, the most widely studied variants of PHGDH are from the E. coli and M. tuberculosis genomes. In humans, this enzyme is encoded by the PHGDH gene.