PDE3 inhibitor

A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic shock.

PDE3 inhibitors produce dilation of resistance and capacitance blood vessels (thus decreasing both preload and afterload), and exhibit positive inotropy and chronotropy. PDE3 inhibitors potentiate the effects of beta-adrenergic agonists.

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