Permease of phosphotransferase system
| Phosphotransferase permease | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PTS | ||||||
| Pfam | PF03611 | ||||||
| InterPro | IPR004703 | ||||||
| TCDB | 4.A.7 | ||||||
| OPM superfamily | 426 | ||||||
| OPM protein | 5zov | ||||||
| |||||||
Permease of phosphotransferase system (or PTS-AG superfamily according to TCDB) is a superfamily of phosphotransferase enzymes that facilitate the transport of L-ascorbate (A) and galactitol (G). Classification has been established through phylogenic analysis and bioinformatics.
The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC). The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies.
The four families that make up the PTS-GFL superfamily include: