PTPN11

PTPN11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG, 4RDD, 4QSY, 5DF6, 5IBS, 5EHP, 5EHR, 5I6V, 5IBM
Identifiers
Aliases	PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11
External IDs	OMIM: 176876; MGI: 99511; HomoloGene: 2122; GeneCards: PTPN11; OMA:PTPN11 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,509,918 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,329,460 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; dorsal motor nucleus of vagus nerve; ; Brodmann area 23; ; visceral pleura; ; parietal pleura; ; subthalamic nucleus; ; pars reticulata; ; inferior olivary nucleus; ; Epithelium of choroid plexus; ; external globus pallidus;
	Top expressed in
	renal corpuscle; ; Epithelium of choroid plexus; ; utricle; ; medullary collecting duct; ; retinal pigment epithelium; ; substantia nigra; ; ciliary body; ; iris; ; endocardial cushion; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; phosphoprotein phosphatase activity; insulin receptor binding; phosphatase activity; receptor tyrosine kinase binding; peptide hormone receptor binding; protein binding; non-membrane spanning protein tyrosine phosphatase activity; hydrolase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; cell adhesion molecule binding; protein tyrosine phosphatase activity; phosphotyrosine residue binding; protein domain specific binding; D1 dopamine receptor binding; insulin receptor substrate binding; protein tyrosine kinase binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; mitochondrion; nucleus; nucleoplasm; protein-containing complex;
Biological process	dephosphorylation; megakaryocyte development; positive regulation of signal transduction; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; atrioventricular canal development; intestinal epithelial cell migration; organ growth; epidermal growth factor receptor signaling pathway; negative regulation of growth hormone secretion; axonogenesis; glucose homeostasis; regulation of protein export from nucleus; multicellular organism growth; regulation of multicellular organism growth; lipid metabolism; ephrin receptor signaling pathway; abortive mitotic cell cycle; DNA damage checkpoint signaling; protein dephosphorylation; T cell costimulation; platelet formation; microvillus organization; positive regulation of mitotic cell cycle; genitalia development; platelet activation; fibroblast growth factor receptor signaling pathway; development of the heart; brain development; regulation of type I interferon-mediated signaling pathway; hormone-mediated signaling pathway; integrin-mediated signaling pathway; Bergmann glial cell differentiation; homeostasis of number of cells within a tissue; inner ear development; platelet-derived growth factor receptor signaling pathway; negative regulation of cortisol secretion; peptidyl-tyrosine dephosphorylation; ERBB signaling pathway; negative regulation of hormone secretion; triglyceride metabolic process; hormone metabolic process; positive regulation of hormone secretion; negative regulation of cell adhesion mediated by integrin; regulation of protein-containing complex assembly; face morphogenesis; cerebellar cortex formation; leukocyte migration; multicellular organismal reproductive process; phosphatidylinositol phosphate biosynthetic process; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-3-phosphate biosynthetic process; axon guidance; positive regulation of ERK1 and ERK2 cascade; cellular response to epidermal growth factor stimulus; positive regulation of protein kinase B signaling; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; cellular response to cytokine stimulus; cellular response to mechanical stimulus; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of glucose import; positive regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5781
	19247
	ENSG00000179295
	ENSMUSG00000043733
	Q06124
	P35235
	NM_002834; NM_080601; NM_001330437; NM_001374625; NM_018508
	NM_001109992; NM_011202
	NP_001317366; NP_002825; NP_542168; NP_001361554
	NP_001103462; NP_035332
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Evolution: Although lost in rodents and higher primates, most jawed vertebrates, including sharks, have a second ancient molecule that is very similar to PTPN11 (SHP-2) and has been named SHP-2like (SHP-2L). In zebrafish, SHP-2 and SHP-2L have overlapping functional abilities. SHP-2 and SHP-2L are quite distinct from SHP-1 (PTPN6).