PSMD4

PSMD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF
Identifiers
Aliases	PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
External IDs	OMIM: 601648; MGI: 1201670; HomoloGene: 55691; GeneCards: PSMD4; OMA:PSMD4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,267,479 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,949,925 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left testis; ; right testis; ; gastrocnemius muscle; ; muscle of thigh; ; right frontal lobe; ; muscle layer of sigmoid colon; ; amygdala; ; C1 segment; ; monocyte;
	Top expressed in
	yolk sac; ; muscle of thigh; ; abdominal wall; ; facial motor nucleus; ; mandibular prominence; ; maxillary prominence; ; temporal muscle; ; lens; ; medial head of gastrocnemius muscle; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	polyubiquitin modification-dependent protein binding; protein binding; identical protein binding; RNA binding;
Cellular component	nucleoplasm; proteasome complex; nucleus; cytosol; proteasome accessory complex; proteasome regulatory particle, base subcomplex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; ubiquitin-dependent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5710
	19185
	ENSG00000159352
	ENSMUSG00000005625
	P55036
	O35226
	NM_002810; NM_153822; NM_001330692
	NM_001282017; NM_008951
	NP_001317621; NP_002801
	NP_001268946; NP_032977
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD4 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.