| PPARGC1A |
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| Identifiers |
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| Aliases | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1, PGC-1alpha, PPARG coactivator 1 alpha, PGC-1α |
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| External IDs | OMIM: 604517; MGI: 1342774; GeneCards: PPARGC1A; OMA:PPARGC1A - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 5 (mouse) |
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| | Band | 5|5 C1 | Start | 51,611,592 bp |
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| End | 51,725,068 bp |
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| Wikidata |
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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes.
PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis.