DNA polymerase alpha catalytic subunit

POLA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K0P, 1K18, 1N5G, 4Q5V, 4QCL, 4Y97, 5EXR, 5IUD
Identifiers
Aliases	POLA1, NSX, POLA, p180, Polymerase (DNA directed), alpha 1, polymerase (DNA) alpha 1, catalytic subunit, DNA polymerase alpha 1, catalytic subunit, VEODS
External IDs	OMIM: 312040; MGI: 99660; HomoloGene: 6802; GeneCards: POLA1; OMA:POLA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	24,996,986 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	92,675,761 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sural nerve; ; Achilles tendon; ; oocyte; ; gonad; ; ganglionic eminence; ; epithelium of colon; ; secondary oocyte; ; testicle; ; bone marrow cell;
	Top expressed in
	morula; ; ureter; ; epiblast; ; blastocyst; ; zygote; ; abdominal wall; ; dermis; ; tail of embryo; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; 4 iron, 4 sulfur cluster binding; nucleotidyltransferase activity; nucleoside binding; iron-sulfur cluster binding; chromatin binding; metal ion binding; protein binding; nucleic acid binding; protein kinase binding; DNA-directed DNA polymerase activity; nucleotide binding; DNA binding; DNA replication origin binding; purine nucleotide binding; protein heterodimerization activity; single-stranded DNA binding; pyrimidine nucleotide binding;
Cellular component	nuclear envelope; nuclear matrix; nucleolus; chromatin; nucleoplasm; nucleus; cytoplasm; cytosol; alpha DNA polymerase:primase complex;
Biological process	DNA synthesis involved in DNA repair; lagging strand elongation; regulation of transcription involved in G1/S transition of mitotic cell cycle; DNA replication; leading strand elongation; cell population proliferation; viral process; double-strand break repair via nonhomologous end joining; DNA strand elongation involved in DNA replication; DNA replication, synthesis of RNA primer; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA replication initiation; DNA repair; nucleotide-excision repair; DNA synthesis involved in UV-damage excision repair; mitotic DNA replication initiation; synthesis of RNA primer involved in mitotic DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	5422
	18968
	ENSG00000101868
	ENSMUSG00000006678
	P09884
	P33609
	NM_016937; NM_001330360; NM_001378303
	NM_008892
	NP_001317289; NP_058633; NP_001365232
	NP_032918
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase alpha catalytic subunit in humans is encoded by the POLA1 gene and is part of the enzyme DNA polymerase alpha.