Plectin

PLEC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I
Identifiers
Aliases	PLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A
External IDs	OMIM: 601282; MGI: 1277961; HomoloGene: 384; GeneCards: PLEC; OMA:PLEC - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,976,734 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,116,774 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; muscle of thigh; ; gastrocnemius muscle; ; stromal cell of endometrium; ; apex of heart; ; body of tongue; ; right coronary artery; ; gastric mucosa; ; nipple; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	ankle; ; internal carotid artery; ; external carotid artery; ; soleus muscle; ; temporal muscle; ; endothelial cell of lymphatic vessel; ; digastric muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ankyrin binding; actin binding; structural constituent of muscle; RNA binding; cytoskeletal protein binding; cadherin binding; structural molecule activity; structural constituent of cytoskeleton;
Cellular component	focal adhesion; plasma membrane; hemidesmosome; cell junction; brush border; sarcoplasm; contractile fiber; sarcolemma; costamere; intermediate filament cytoskeleton; extracellular exosome; cytoskeleton; extracellular matrix; cytoplasm; cytosol; intermediate filament; membrane; perinuclear region of cytoplasm;
Biological process	hemidesmosome assembly; cytoskeleton organization; wound healing; intermediate filament cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	5339
	18810
	ENSG00000178209
	ENSMUSG00000022565
	Q15149
	Q9QXS1
NM_000445; NM_201378; NM_201379; NM_201380; NM_201381;
	NM_201382; NM_201383; NM_201384
NM_001163540; NM_001163542; NM_001163549; NM_001164203; NM_011117;
	NM_201385; NM_201386; NM_201387; NM_201388; NM_201389; NM_201390; NM_201391; NM_201392; NM_201393; NM_201394
NP_000436; NP_958780; NP_958781; NP_958782; NP_958783;
	NP_958784; NP_958785; NP_958786
NP_001157012; NP_001157014; NP_001157021; NP_001157675; NP_035247;
	NP_958787; NP_958788; NP_958789; NP_958790; NP_958791; NP_958792; NP_958793; NP_958794; NP_958795; NP_958796
	Wikidata
View/Edit Human	View/Edit Mouse

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues.