PLCB1

PLCB1
Identifiers
Aliases	PLCB1, EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B, PLC-beta-1, phospholipase C beta 1, DEE12
External IDs	OMIM: 607120; MGI: 97613; HomoloGene: 22876; GeneCards: PLCB1; OMA:PLCB1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	8,968,360 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	135,317,178 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; superior frontal gyrus; ; middle temporal gyrus; ; postcentral gyrus; ; primary visual cortex; ; Brodmann area 10; ; Brodmann area 46; ; frontal pole; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; subiculum; ; Region I of hippocampus proper; ; globus pallidus; ; lateral septal nucleus; ; facial motor nucleus; ; anterior amygdaloid area; ; piriform cortex; ; primary motor cortex; ; anterior horn of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; GTPase activator activity; signal transducer activity; protein binding; phosphoric diester hydrolase activity; enzyme binding; phosphatidylinositol-4,5-bisphosphate binding; hydrolase activity; lamin binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; calmodulin binding;
Cellular component	cytoplasm; cytosol; nuclear speck; nuclear membrane; membrane; myelin sheath; extracellular exosome; nucleus; postsynapse; glutamatergic synapse; GABA-ergic synapse; protein-containing complex;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; glutamate receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-15-mediated signaling pathway; intracellular signal transduction; positive regulation of developmental growth; phosphatidylinositol metabolic process; negative regulation of monocyte extravasation; positive regulation of interleukin-12 production; regulation of G protein-coupled receptor signaling pathway; lipid metabolism; inositol phosphate metabolic process; positive regulation of JNK cascade; memory; regulation of cell cycle; positive regulation of transcription, DNA-templated; lipid catabolic process; positive regulation of G1/S transition of mitotic cell cycle; interleukin-1-mediated signaling pathway; positive regulation of acrosome reaction; brain development; G2/M transition of mitotic cell cycle; interleukin-12-mediated signaling pathway; positive regulation of myoblast differentiation; positive regulation of CD24 production; cerebral cortex development; activation of meiosis involved in egg activation; regulation of fertilization; positive regulation of embryonic development; negative regulation of transcription, DNA-templated; fat cell differentiation; signal transduction; Wnt signaling pathway, calcium modulating pathway; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway; postsynaptic modulation of chemical synaptic transmission; regulation of retrograde trans-synaptic signaling by endocanabinoid; inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	23236
	18795
	ENSG00000182621
	ENSMUSG00000051177
	Q9NQ66
	Q9Z1B3
	NM_015192; NM_182734
	NM_001145830; NM_019677
	NP_056007; NP_877398
	NP_001139302; NP_062651
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.