PLAT domain
| PLAT/LH2 domain | |||||||
|---|---|---|---|---|---|---|---|
Structure of the lipase-procolipase complex. | |||||||
| Identifiers | |||||||
| Symbol | PLAT | ||||||
| Pfam | PF01477 | ||||||
| InterPro | IPR001024 | ||||||
| SMART | SM00308 | ||||||
| PROSITE | PDOC50095 | ||||||
| SCOP2 | 1lpa / SCOPe / SUPFAM | ||||||
| OPM superfamily | 221 | ||||||
| OPM protein | 3swz | ||||||
| CDD | cd00113 | ||||||
| |||||||
In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.
This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.