PLA2G6

PLA2G6
Identifiers
Aliases	PLA2G6, CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta, phospholipase A2 group VI
External IDs	OMIM: 603604; MGI: 1859152; HomoloGene: 2635; GeneCards: PLA2G6; OMA:PLA2G6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,214,778 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,328,390 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder; ; right adrenal cortex; ; sural nerve; ; granulocyte; ; right testis; ; left ovary; ; left testis;
	Top expressed in
	gastrula; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; muscle of thigh; ; left lobe of liver; ; transitional epithelium of urinary bladder; ; islet of Langerhans; ; yolk sac; ; brown adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase A2 activity; ATP-dependent protein binding; calmodulin binding; calcium-independent phospholipase A2 activity; hydrolase activity; serine hydrolase activity; protein kinase binding;
Cellular component	membrane; microtubule organizing center; mitochondrion; extracellular space; cytoplasm; cytosol;
Biological process	positive regulation of ceramide biosynthetic process; positive regulation of protein phosphorylation; phosphatidylethanolamine acyl-chain remodeling; urinary bladder smooth muscle contraction; maternal process involved in female pregnancy; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of store-operated calcium channel activity; positive regulation of protein kinase C signaling; lipid metabolism; positive regulation of cytosolic calcium ion concentration; antibacterial humoral response; memory; response to endoplasmic reticulum stress; chemotaxis; lipid catabolic process; positive regulation of arachidonic acid secretion; cardiolipin biosynthetic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; metabolism; negative regulation of synaptic transmission, glutamatergic; phosphatidylcholine acyl-chain remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8398
	53357
	ENSG00000184381
	ENSMUSG00000042632
	O60733
	P97819
NM_001004426; NM_001199562; NM_003560; NM_001349864; NM_001349865;
	NM_001349866; NM_001349867; NM_001349868; NM_001349869
	NM_001199023; NM_001199024; NM_001199025; NM_016915
NP_001004426; NP_001186491; NP_003551; NP_001336793; NP_001336794;
	NP_001336795; NP_001336796; NP_001336797; NP_001336798
	NP_001185952; NP_001185953; NP_001185954; NP_058611
	Wikidata
View/Edit Human	View/Edit Mouse

85 kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, or Patatin-like phospholipase domain-containing protein 9 is an enzyme that in humans is encoded by the PLA2G6 gene.