P110α

PIK3CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP
Identifiers
Aliases	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, CLAPO, CCM4
External IDs	OMIM: 171834; MGI: 1206581; HomoloGene: 21249; GeneCards: PIK3CA; OMA:PIK3CA - orthologs
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	179,240,093 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	32,522,635 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gonad; ; testicle; ; tendon of biceps brachii; ; ventricular zone; ; secondary oocyte; ; ganglionic eminence; ; cartilage tissue; ; right ventricle; ; skin of hip;
	Top expressed in
	Rostral migratory stream; ; lacrimal gland; ; iris; ; mammillary body; ; lobe of cerebellum; ; lateral geniculate nucleus; ; ascending aorta; ; cerebellar vermis; ; genital tubercle; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activator activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; protein serine/threonine kinase activity; protein binding; insulin receptor substrate binding; ATP binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; kinase activity; phosphatidylinositol 3-kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity;
Cellular component	phosphatidylinositol 3-kinase complex; cytosol; phosphatidylinositol 3-kinase complex, class IA; plasma membrane; lamellipodium; cytoplasm; membrane;
Biological process	negative regulation of neuron apoptotic process; cardiac muscle contraction; epidermal growth factor receptor signaling pathway; protein kinase B signaling; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of multicellular organism growth; T cell costimulation; hypomethylation of CpG island; positive regulation of peptidyl-serine phosphorylation; platelet activation; Fc-epsilon receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; vascular endothelial growth factor receptor signaling pathway; vasculature development; angiogenesis; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; glucose metabolic process; phagocytosis; energy homeostasis; negative regulation of fibroblast apoptotic process; regulation of gene expression; liver development; adipose tissue development; regulation of cellular respiration; T cell receptor signaling pathway; activation of protein kinase activity; regulation of genetic imprinting; negative regulation of anoikis; cellular response to glucose stimulus; endothelial cell migration; phosphatidylinositol-mediated signaling; leukocyte migration; ERBB2 signaling pathway; phosphatidylinositol-3-phosphate biosynthetic process; axon guidance; negative regulation of macroautophagy; phosphorylation; positive regulation of TOR signaling; anoikis; adaptive immune response; protein phosphorylation; inflammatory response; innate immune response; cell chemotaxis; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; phosphatidylinositol 3-kinase signaling; cytokine-mediated signaling pathway; cell migration; positive regulation of phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; regulation of protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5290
	18706
	ENSG00000121879
	ENSMUSG00000027665
	P42336
	P42337
	NM_006218
	NM_008839
	NP_006209
	NP_032865
	Wikidata
View/Edit Human	View/Edit Mouse

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene.

Its role was uncovered by molecular pathological epidemiology (MPE).