PHD finger
| PHD-finger | |||||||
|---|---|---|---|---|---|---|---|
PHD zinc finger. Zinc atoms shown in grey | |||||||
| Identifiers | |||||||
| Symbol | PHD | ||||||
| Pfam | PF00628 | ||||||
| Pfam clan | CL0390 | ||||||
| InterPro | IPR019787 | ||||||
| PROSITE | PS50016 | ||||||
| SCOP2 | 1f62 / SCOPe / SUPFAM | ||||||
| OPM superfamily | 59 | ||||||
| OPM protein | 1vfy | ||||||
| |||||||
The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in Arabidopsis and maize ZmHox1a. The PHD zinc finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.