PHB2

PHB2
Identifiers
Aliases	PHB2, BAP, BCAP37, Bap37, PNAS-141, REA, p22, hBAP, prohibitin 2, Prohibitin-2
External IDs	OMIM: 610704; MGI: 102520; HomoloGene: 5263; GeneCards: PHB2; OMA:PHB2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,970,780 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,693,913 bp
RNA expression pattern
	Top expressed in
	vulva; ; nipple; ; skin of arm; ; vastus lateralis muscle; ; triceps brachii muscle; ; left ovary; ; jejunal mucosa; ; skin of thigh; ; thymus; ; glutes;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; tail of embryo; ; right kidney; ; lip; ; esophagus; ; muscle of thigh; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein N-terminus binding; amide binding; protein C-terminus binding; protein binding; estrogen receptor binding; sphingolipid binding;
Cellular component	cytoplasm; membrane; nuclear matrix; cell surface; mitochondrial outer membrane; mitochondrion; extracellular exosome; nucleus; cell periphery; mitochondrial inner membrane; axon; postsynaptic density; protein-containing complex; presynaptic active zone; glutamatergic synapse; GABA-ergic synapse;
Biological process	regulation of transcription, DNA-templated; mammary gland branching involved in thelarche; protein stabilization; regulation of branching involved in mammary gland duct morphogenesis; mitochondrion organization; negative regulation of mammary gland epithelial cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of exit from mitosis; mammary gland alveolus development; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; sister chromatid cohesion; positive regulation of cell cycle G1/S phase transition; positive regulation of ERK1 and ERK2 cascade; negative regulation of transcription, DNA-templated; negative regulation of intracellular estrogen receptor signaling pathway; regulation of complement activation; mitochondrial calcium ion transmembrane transport; response to wounding; negative regulation of apoptotic process; cellular response to retinoic acid; cellular response to hypoxia; protein import into nucleus; regulation of cytochrome-c oxidase activity;
	Sources:Amigo / QuickGO
Orthologs
	11331
	12034
	ENSG00000215021
	ENSMUSG00000004264
	Q99623
	O35129
	NM_001144831; NM_001267700
	NM_007531
	NP_001138303; NP_001254629
	NP_031557
	Wikidata
View/Edit Human	View/Edit Mouse

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.