PGDS

HPGDS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IYH, 1IYI, 1V40, 2CVD, 2VCQ, 2VCW, 2VCX, 2VCZ, 2VD0, 2VD1, 3EE2, 3KXO, 3VI5, 3VI7, 4EC0, 4EDY, 4EDZ, 4EE0, 5AIS, 5AIV, 5AIX
Identifiers
Aliases	HPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDs	OMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs
EC number	2.5.1.18
Gene location (Human)
Chr.	Chromosome 4 (human)
End	94,342,876 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	65,121,892 bp
RNA expression pattern
	Top expressed in
	testicle; ; placenta; ; Achilles tendon; ; gallbladder; ; synovial membrane; ; amniotic fluid; ; mucosa of transverse colon; ; rectum; ; synovial joint; ; tendon of biceps brachii;
	Top expressed in
	genital tubercle; ; primordial germ cell; ; calvaria; ; stroma of bone marrow; ; hair; ; Sertoli cell; ; yolk sac; ; ooblast; ; cornea; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; calcium ion binding; protein homodimerization activity; isomerase activity; metal ion binding; prostaglandin-D synthase activity; protein binding; magnesium ion binding; glutathione transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	prostaglandin metabolic process; locomotory behavior; lipid metabolism; cyclooxygenase pathway; fatty acid metabolic process; fatty acid biosynthetic process; prostaglandin biosynthetic process; glutathione derivative biosynthetic process; signal transduction; negative regulation of male germ cell proliferation; glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27306
	54486
	ENSG00000163106
	ENSMUSG00000029919
	O60760
	Q9JHF7
	NM_014485
	NM_019455
	NP_055300
	NP_062328
	Wikidata
View/Edit Human	View/Edit Mouse

(Hematopoietic) PGDS protein, also known as Glutathione-Dependent PGD Synthase, is a protein that in humans is encoded by the HPGDS gene.

Gluthionine-dependent Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. As a type of Prostaglandin-D synthase, it catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.