PAK3

PAK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EES
Identifiers
Aliases	PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK-3, beta-PAK, ARA, p21 (RAC1) activated kinase 3, XLID30
External IDs	OMIM: 300142; MGI: 1339656; HomoloGene: 55664; GeneCards: PAK3; OMA:PAK3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	111,227,361 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	142,580,792 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; entorhinal cortex; ; orbitofrontal cortex; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; lateral nuclear group of thalamus; ; Region I of hippocampus proper;
	Top expressed in
	ventromedial nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; anterior amygdaloid area; ; arcuate nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; SH3 domain binding; metal ion binding; kinase activity; protein binding; catalytic activity; GTPase binding; ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; cytosol; endosome; plasma membrane; postsynaptic density; glutamatergic synapse;
Biological process	regulation of neuron projection development; phosphorylation; ephrin receptor signaling pathway; dendrite development; T cell costimulation; synapse organization; cellular response to organic cyclic compound; stimulatory C-type lectin receptor signaling pathway; multicellular organism development; protein phosphorylation; regulation of actin filament polymerization; positive regulation of neuron apoptotic process; dendritic spine development; positive regulation of DNA biosynthetic process; metabolism; T cell receptor signaling pathway; positive regulation of dendritic spine morphogenesis; MAPK cascade; regulation of actin cytoskeleton organization; positive regulation of fibroblast migration; dendritic spine morphogenesis; Rho protein signal transduction; regulation of mitotic cell cycle; axonogenesis; cell migration; stress-activated protein kinase signaling cascade; regulation of axonogenesis; regulation of apoptotic process; signal transduction; activation of protein kinase activity; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	5063
	18481
	ENSG00000077264
	ENSMUSG00000031284
	O75914
	Q61036
NM_001128166; NM_001128167; NM_001128168; NM_001128172; NM_001128173;
	NM_002578; NM_001324325; NM_001324326; NM_001324327; NM_001324328; NM_001324329; NM_001324330; NM_001324331; NM_001324332; NM_001324333; NM_001324334
	NM_001195046; NM_001195047; NM_001195048; NM_001195049; NM_008778
NP_001121638; NP_001121639; NP_001121640; NP_001121644; NP_001121645;
	NP_001311254; NP_001311255; NP_001311256; NP_001311257; NP_001311258; NP_001311259; NP_001311260; NP_001311261; NP_001311262; NP_001311263; NP_002569
	NP_001181975; NP_001181976; NP_001181977; NP_001181978; NP_032804
	Wikidata
View/Edit Human	View/Edit Mouse

PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. PAK3 is preferentially expressed in neuronal cells and involved in synapse formation and plasticity and mental retardation.