PAAT (protein)

C10orf88
Identifiers
AliasesC10orf88, chromosome 10 open reading frame 88, PAAT
External IDsMGI: 1915527; HomoloGene: 11793; GeneCards: C10orf88; OMA:C10orf88 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

80007

68277

Ensembl

ENSG00000119965

ENSMUSG00000040177

UniProt

Q9H8K7

Q9D2Q3

RefSeq (mRNA)

NM_024942

NM_026655

RefSeq (protein)

NP_079218

NP_080931

Location (UCSC)Chr 10: 122.93 – 122.95 MbChr 7: 130.94 – 130.96 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

PAAT (protein associated with ABC transporters), also known as C10orf88 (chromosome 10 open reading frame 88), is a protein in the human genome, encoding by the gene of the same name. It is predicted to be associated with ABC transporters, containing an ABC transporter domain, specifically Type II ABC Transporters. PAAT physically interacts with mitochondrial inner membrane ABC transporters, and plays a functional role in ferric nutrient transport and heme biosynthesis. The gene has been strongly associated with a rare form of Alzheimer's disease, and is primarily expressed in the cerebral cortex, testis, and thymus. It is mainly localized in the cytoplasm and nucleus.