Ovomucoid
| Ovomucoid | |||||||
|---|---|---|---|---|---|---|---|
The third Kazal domain of the turkey ovomucoid protein (orange) bound to subtilisin Carlsberg, a serine protease. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | OVAL | ||||||
| Entrez | 100541469 | ||||||
| RefSeq (mRNA) | XM_031555706.1 | ||||||
| RefSeq (Prot) | XP_031411566.1 | ||||||
| UniProt | P68390 | ||||||
| Other data | |||||||
| Chromosome | 15: 9.8 - 9.81 Mb | ||||||
| |||||||
| Ovomucoid | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | OVAL | ||||||
| Entrez | 396058 | ||||||
| RefSeq (mRNA) | NM_205152.3 | ||||||
| RefSeq (Prot) | NP_990483.2 | ||||||
| UniProt | P01005 | ||||||
| Other data | |||||||
| Chromosome | 2: 67.42 - 67.43 Mb | ||||||
| |||||||
Ovomucoid is a protein found in egg whites. Ovomucoid's main source are various avian species like chickens (Gallus gallus domesticus) and ducks (Anatidae). It makes up approximately 11% of proteins found in egg whites.
It is a trypsin inhibitor composed of three protein domains of the Kazal domain family. The homologs from chickens (Gallus gallus) and especially turkeys (Meleagris gallopavo) are the best characterized. It is not related to the similarly named ovomucin, another egg white protein.
Chicken ovomucoid, also known as Gal d 1, is a known allergen. It is the protein most often causing egg allergy. At least four IgE epitopes have been identified. Three other egg white proteins are also identified as allergenic: ovalbumin (Gal d 2), ovotransferrin (Gal d 3) and lysozyme (Gal d 4).