Organelle biogenesis

Organelle biogenesis refers to the processes by which eukaryotic cells form, grow, maintain, and distribute their intracellular organelles. Many organelles proliferate by growth and division of pre‑existing structures, while others (notably peroxisomes and lipid droplets) can also arise *de novo* from precursor membranes of the endoplasmic reticulum (ER).

Organelle abundance and composition are regulated by developmental and metabolic cues, and defects in biogenesis contribute to human disease. Peroxisome biogenesis disorders (Zellweger spectrum) exemplify how failure to assemble or maintain a class of organelles can lead to severe metabolic pathology.

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