Hypocretin (orexin) receptor 2

Available protein structures:
PDB	IPR004060 PF03827 (ECOD; PDBsum)
AlphaFold	IPR004060; PF03827;

Orexin receptor type 2
Orexin receptor type 2
Identifiers
Symbol	Orexin_rec2
Pfam	PF03827
InterPro	IPR004060
PDB
Available protein structures:
PDB	IPR004060 PF03827 (ECOD; PDBsum)
AlphaFold	IPR004060; PF03827;

HCRTR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4S0V
Identifiers
Aliases	HCRTR2, OX2R, Hypocretin (orexin) receptor 2, hypocretin receptor 2, ORXR2, OXR2
External IDs	OMIM: 602393; MGI: 2680765; HomoloGene: 1168; GeneCards: HCRTR2; OMA:HCRTR2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	55,282,617 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	76,231,138 bp
RNA expression pattern
	Top expressed in
	testicle; ; prefrontal cortex; ; pons; ; hypothalamus; ; Achilles tendon; ; gonad; ; Brodmann area 9; ; ventricular zone; ; superior vestibular nucleus; ; ganglionic eminence;
	Top expressed in
	morula; ; embryo; ; spinal ganglia; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; neural tube; ; superior frontal gyrus; ; blastocyst; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide hormone binding; peptide binding; G protein-coupled receptor activity; signal transducer activity; neuropeptide receptor activity; orexin receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; regulation of circadian sleep/wake cycle, sleep; circadian sleep/wake cycle process; signal transduction; response to peptide; chemical synaptic transmission; regulation of cytosolic calcium ion concentration; regulation of circadian sleep/wake cycle, wakefulness; neuropeptide signaling pathway; feeding behavior; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3062
	387285
	ENSG00000137252
	ENSMUSG00000032360
	O43614
	P58308
	NM_001526; NM_001384272
	NM_198962; NM_001364551
	NP_001517
	NP_945200; NP_001351480
	Wikidata
View/Edit Human	View/Edit Mouse

Orexin receptor type 2 (Ox2R or OX₂), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.