Protein O-GlcNAc transferase

OGT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W3B, 3PE3, 3PE4, 3TAX, 4AY5, 4AY6, 4CDR, 4GYW, 4GYY, 4GZ3, 4GZ5, 4GZ6, 4N39, 4N3A, 4N3B, 4XI9, 4XIF, 5BNW, 5C1D
Identifiers
Aliases	OGT, HRNT1, O-GLCNAC, HINCUT-1, O-linked N-acetylglucosamine (GlcNAc) transferase, OGT1, MRX106, XLID106
External IDs	OMIM: 300255; MGI: 1339639; HomoloGene: 9675; GeneCards: OGT; OMA:OGT - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	71,575,892 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,727,957 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; skin of hip; ; right uterine tube; ; tibia; ; visceral pleura; ; epithelium of nasopharynx; ; skin of thigh; ; parietal pleura; ; trabecular bone;
	Top expressed in
	medullary collecting duct; ; genital tubercle; ; utricle; ; granulocyte; ; olfactory bulb; ; iris; ; cerebellar cortex; ; dorsal striatum; ; vas deferens; ; lobe of cerebellum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; transferase activity; acetylglucosaminyltransferase activity; glycosyltransferase activity; histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific); protein O-GlcNAc transferase activity; protein binding; histone acetyltransferase activity (H4-K16 specific); phosphatidylinositol-3,4,5-trisphosphate binding; protein N-acetylglucosaminyltransferase activity;
Cellular component	cytoplasm; membrane; plasma membrane; mitochondrion; histone acetyltransferase complex; nucleus; cytosol; nucleoplasm; protein-containing complex; mitochondrial membranes; cell projection; protein N-acetylglucosaminyltransferase complex;
Biological process	response to nutrient; rhythmic process; histone H3-K4 trimethylation; protein O-linked glycosylation; regulation of Rac protein signal transduction; circadian regulation of gene expression; regulation of glycolytic process; histone H4-K5 acetylation; response to insulin; protein glycosylation; positive regulation of proteolysis; positive regulation of histone H3-K27 methylation; histone H4-K16 acetylation; histone H4-K8 acetylation; phosphatidylinositol-mediated signaling; signal transduction; positive regulation of transcription by RNA polymerase II; regulation of insulin receptor signaling pathway; apoptotic process; protein deubiquitination; protein processing; regulation of transcription by RNA polymerase II; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; chromatin organization; regulation of gluconeogenesis; viral process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8473
	108155
	ENSG00000147162
	ENSMUSG00000034160
	O15294
	Q8CGY8
	NM_003605; NM_181672; NM_181673; NM_025192
	NM_001290535; NM_139144
	NP_858058; NP_858059
	NP_001277464; NP_631883
	Wikidata
View/Edit Human	View/Edit Mouse

Protein O-GlcNAc transferase also known as OGT or O-linked N-acetylglucosaminyltransferase is an enzyme (EC 2.4.1.255) that in humans is encoded by the OGT gene. OGT catalyzes the addition of the O-GlcNAc post-translational modification to proteins.