Oxoguanine glycosylase

Available protein structures:
PDB	IPR012904 PF07934 (ECOD; PDBsum)
AlphaFold	IPR012904; PF07934;

8-oxoguanine DNA glycosylase, N-terminal domain
8-oxoguanine DNA glycosylase, N-terminal domain
	structure of catalytically inactive q315a human 8-oxoguanine glycosylase complexed to 8-oxoguanine dna
Identifiers
Symbol	OGG_N
Pfam	PF07934
Pfam clan	CL0407
InterPro	IPR012904
SCOP2	1ebm / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR012904 PF07934 (ECOD; PDBsum)
AlphaFold	IPR012904; PF07934;

OGG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EBM, 1FN7, 1HU0, 1KO9, 1LWV, 1LWW, 1LWY, 1M3H, 1M3Q, 1N39, 1N3A, 1N3C, 1YQK, 1YQL, 1YQM, 1YQR, 2I5W, 2NOB, 2NOE, 2NOF, 2NOH, 2NOI, 2NOL, 2NOZ, 2XHI, 3IH7, 3KTU, 5AN4
Identifiers
Aliases	OGG1, HMMH, HMUTM, OGH1, 8-oxoguanine DNA glycosylase
External IDs	OMIM: 601982; MGI: 1097693; HomoloGene: 1909; GeneCards: OGG1; OMA:OGG1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	9,788,219 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,312,029 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; oocyte; ; right ovary; ; left ovary; ; human kidney; ; body of uterus; ; granulocyte; ; parotid gland; ; left uterine tube;
	Top expressed in
	spermatocyte; ; spermatid; ; granulocyte; ; yolk sac; ; zygote; ; tail of embryo; ; ventricular zone; ; blastocyst; ; seminiferous tubule; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; microtubule binding; hydrolase activity, acting on glycosyl bonds; oxidized purine DNA binding; catalytic activity; protein binding; oxidized purine nucleobase lesion DNA N-glycosylase activity; lyase activity; endonuclease activity; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; hydrolase activity; damaged DNA binding; DNA N-glycosylase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cellular component	mitochondrion; nuclear matrix; nucleus; nuclear speck; nucleoplasm; protein-containing complex;
Biological process	depurination; nucleotide-excision repair; response to estradiol; regulation of transcription, DNA-templated; response to light stimulus; ageing; negative regulation of apoptotic process; cellular response to cadmium ion; response to oxidative stress; depyrimidination; acute inflammatory response; response to radiation; response to folic acid; metabolism; response to ethanol; nucleotide-excision repair, DNA incision; negative regulation of double-strand break repair via single-strand annealing; base-excision repair; cellular response to DNA damage stimulus; DNA repair; base-excision repair, AP site formation; telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	4968
	18294
	ENSG00000114026
	ENSMUSG00000030271
	O15527
	O08760
NM_002542; NM_016819; NM_016820; NM_016821; NM_016826;
	NM_016827; NM_016828; NM_016829; NM_001354648; NM_001354649; NM_001354650; NM_001354651; NM_001354652
	NM_010957
NP_002533; NP_058212; NP_058213; NP_058214; NP_058434;
	NP_058436; NP_058437; NP_058438; NP_001341577; NP_001341578; NP_001341579; NP_001341580; NP_001341581; NP_058436.1; NP_058434.1
	NP_035087
	Wikidata
View/Edit Human	View/Edit Mouse

8-Oxoguanine glycosylase, also known as OGG1, is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species.