DDT

Dichlorodiphenyltrichloroethane
Names
	IUPAC name 1,1,1-Trichloro-bis-2,2(4-chlorophenyl)ethane
	Preferred IUPAC name 1,1′-(2,2,2-Trichloroethane-1,1-diyl)bis(4-chlorobenzene)
	Other names Dichlorodiphenyltrichloroethane (DDT); Clofenotane
Identifiers
CAS Number	50-29-3 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16130 ;
ChEMBL	ChEMBL416898 ;
ChemSpider	2928 ;
ECHA InfoCard	100.000.023
KEGG	D07367 ;
PubChem CID	3036;
UNII	CIW5S16655 ;
CompTox Dashboard (EPA)	DTXSID4020375 ;
	InChI InChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H Key: YVGGHNCTFXOJCH-UHFFFAOYSA-N ; InChI=1/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H Key: YVGGHNCTFXOJCH-UHFFFAOYAJ;
	SMILES ClC1=CC=C(C(C(Cl)(Cl)Cl)C2=CC=C(C=C2)Cl)C=C1;
Properties
Chemical formula	C14H9Cl5
Molar mass	354.48 g·mol−1
Density	0.99 g/cm3
Melting point	108.5 °C (227.3 °F; 381.6 K)
Boiling point	260 °C (500 °F; 533 K) (decomposes)
Solubility in water	25 μg/L (25 °C)
Pharmacology
ATCvet code	QP53AB01 (WHO)
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Toxic, dangerous to the environment, suspected carcinogen
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H301, H351, H372, H410
Precautionary statements	P203, P260, P264, P270, P280, P301+P316, P318, P319, P321, P330, P391, P405, P501
NFPA 704 (fire diamond)	2 2 0
Flash point	72–77 °C; 162–171 °F; 345–350 K
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	113–800 mg/kg (rat, oral); 250 mg/kg (rabbit, oral); 135 mg/kg (mouse, oral); 150 mg/kg (guinea pig, oral)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 1 mg/m3 [skin]
REL (Recommended)	Ca TWA 0.5 mg/m3
IDLH (Immediate danger)	500 mg/m3
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Dichlorodiphenyltrichloroethane (DDT) is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochloride. Originally developed as an insecticide, it became infamous for its environmental impacts. DDT was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939. DDT was used in the second half of World War II to limit the spread of the insect-borne diseases malaria and typhus among civilians and troops. Müller was awarded the Nobel Prize in Physiology or Medicine in 1948 "for his discovery of the high efficiency of DDT as a contact poison against several arthropods". The World Health Organization's (WHO) anti-malaria campaign of the 1950s and 1960s relied heavily on DDT and the results were promising, though there was a resurgence in developing countries afterwards.

The widespread use of DDT after World War II soon raised environmental concerns, highlighted in the United States by Rachel Carson's 1962 book Silent Spring, which helped spur public opposition and contributed to the 1972 US ban on its agricultural use. The restrictions by governments worldwide that followed were also driven by growing evidence of environmental, wildlife and health harm, and the evolution of insect resistance to DDT. These measures aided the recovery of endangered species. Agricultural use was later largely banned worldwide under the Stockholm Convention on Persistent Organic Pollutants of 2004, although limited public-health use for malaria control remains permitted under WHO guidelines.

DDT is still used in some vector control programmes because of its effectiveness against mosquitoes that transmit malaria, but its use remains controversial due to environmental and health concerns. DDT is one of many tools to fight malaria, which remains the primary public health challenge in many countries. WHO guidelines require confirmation that mosquito populations have not developed resistance before DDT is deployed; such resistance is largely attributed to agricultural use in far greater quantities than needed for disease control.