Nuclear receptor coactivator 3

NCOA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KBH, 3L3X, 3L3Z
Identifiers
Aliases	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, nuclear receptor coactivator 3
External IDs	OMIM: 601937; MGI: 1276535; HomoloGene: 4764; GeneCards: NCOA3; OMA:NCOA3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	47,656,877 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,073,242 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tendon of biceps brachii; ; epithelium of nasopharynx; ; buccal mucosa cell; ; nipple; ; superficial temporal artery; ; bone marrow cell; ; oral cavity; ; palpebral conjunctiva; ; parotid gland;
	Top expressed in
	zygote; ; secondary oocyte; ; granulocyte; ; blood; ; medulla of thymus; ; ciliary body; ; morula; ; ascending aorta; ; primary oocyte; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein dimerization activity; protein N-terminus binding; transcription coactivator activity; thyroid hormone receptor binding; histone acetyltransferase activity; protein binding; androgen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; acyltransferase activity; protein heterodimerization activity; disordered domain specific binding; RNA polymerase II complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; extracellular exosome; nucleus; cytosol; protein-containing complex;
Biological process	androgen receptor signaling pathway; regulation of RNA biosynthetic process; regulation of transcription, DNA-templated; positive regulation of keratinocyte differentiation; cellular response to estradiol stimulus; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; receptor transactivation; intracellular receptor signaling pathway; histone acetylation; cellular response to hormone stimulus; cell dedifferentiation; positive regulation of stem cell population maintenance; regulation of stem cell division;
	Sources:Amigo / QuickGO
Orthologs
	8202
	17979
	ENSG00000124151
	ENSMUSG00000027678
	Q9Y6Q9
	O09000
	NM_181659; NM_001174087; NM_001174088; NM_006534
	NM_008679; NM_001374779
	NP_001167558; NP_001167559; NP_006525; NP_858045
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).