Norketotifen

Norketotifen
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
EC Number
  • 806-081-6
  • InChI=1S/C18H17NOS/c20-16-11-13-3-1-2-4-14(13)17(12-5-8-19-9-6-12)15-7-10-21-18(15)16/h1-4,7,10,19H,5-6,8-9,11H2
    Key: IYSYPCSSDZBWHN-UHFFFAOYSA-N
  • C1CNCCC1=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3
Properties
C18H17NOS
Molar mass 295.4
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Norketotifen is a pharmaceutical medication under research, which is not yet approved for use. It is undergoing clinical trials. Norketotifen is a biologically active demethylated metabolite of ketotifen and has a similar potency as ketotifen as an antihistamine H1 medication and a mast cell stabilizer, yet is likely devoid of sedative effects of ketotifen, potentially allowing for higher doses to be administered without sedation as a limiting factor. Norketotifen is researched for its potential anti-inflammatory activity caused by dose-dependent inhibition of the release of the pro-inflammatory cytokine TNF-α, and for its other potential properties.

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