Nicotyrine

Nicotyrine
Names
	IUPAC name 3-(1-methylpyrrol-2-yl)pyridine
	Other names alpha-nicotyrine; beta-nicotyrine; ss-nicotyrine; 3,2'-nicotyrine;
Identifiers
CAS Number	487-19-4;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:7564;
ChEMBL	ChEMBL1522291;
ChemSpider	2282468;
ECHA InfoCard	100.006.956
EC Number	207-651-1;
KEGG	C10161;
PubChem CID	10249;
UNII	XN4R1LH79Y;
CompTox Dashboard (EPA)	DTXSID3075048 ;
	InChI InChI=1S/C10H10N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2-8H,1H3 Key: RYFOJXFXERAMLS-UHFFFAOYSA-N;
	SMILES CN1C=CC=C1C2=CN=CC=C2;
Properties
Chemical formula	C10H10N2
Molar mass	158.204 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Nicotryine is lesser known and minor tobacco alkaloid. It inhibits metabolism of nicotine through CYP2A6 enzyme inhibition (K_i = 7.5 ± 2.9). It also inhibits CYP2A13 (K_i = 5.6 ± 0.86) which might play role in nicotine metabolism. Nicotyrine is formed by gradual oxidation of nicotine in e-liquids and causes delayed nicotine clearance and attenuated withdrawal symptoms.

It has insecticidal properties like nicotine and certain derivatives have been synthesized for that property.