Neuropeptide FF

NPFF
Identifiers
Aliases	NPFF, FMRFAL, neuropeptide FF-amide peptide precursor
External IDs	OMIM: 604643; MGI: 1891708; HomoloGene: 48236; GeneCards: NPFF; OMA:NPFF - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,507,484 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,433,377 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; epithelium of colon; ; granulocyte; ; ganglionic eminence; ; apex of heart; ; olfactory zone of nasal mucosa; ; C1 segment; ; stromal cell of endometrium; ; mucosa of transverse colon;
	Top expressed in
	bone marrow; ; pancreas; ; islet of Langerhans; ; adrenal gland; ; urinary bladder; ; skeletal muscle tissue; ; morula; ; zone of skin; ; white adipose tissue; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; G protein-coupled receptor binding; neuropeptide hormone activity;
Cellular component	vesicle; extracellular region; postsynapse; extracellular space; dendrite; perikaryon; axon terminus;
Biological process	negative regulation of insulin secretion; regulation of sensory perception of pain; maternal process involved in female pregnancy; positive regulation of cytosolic calcium ion concentration; acute inflammatory response to antigenic stimulus; negative regulation of appetite; vasopressin secretion; regulation of membrane depolarization; negative regulation of heart rate; response to morphine; positive regulation of blood pressure; spinal cord development; neuropeptide signaling pathway; somatostatin secretion; chemical synaptic transmission; excitatory postsynaptic potential; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8620
	54615
	ENSG00000139574
	ENSMUSG00000023052
	O15130
	Q9WVA8
	NM_003717; NM_001320296
	NM_018787
	NP_001307225; NP_003708
	NP_061257
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide FF (NPFF, FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.

In humans, neuropeptide FF peptides are encoded by the NPFF gene. Two genes encoding two different receptors (NPFF1 and NPFF2) and two precursors [NPFFA (this gene) and NPFFB (NPVF)] have been cloned in several mammalian species.