Napabucasin

Napabucasin
Clinical data
Drug classSTAT3 inhibitor
Identifiers
  • 2-acetylbenzo[f][1]benzofuran-4,9-dione
CAS Number
PubChem CID
Chemical and physical data
FormulaC14H8O4
Molar mass240.214 g·mol−1
3D model (JSmol)
  • CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O
  • InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
  • Key:DPHUWDIXHNQOSY-UHFFFAOYSA-N

Napabucasin (BBI-608) is a natural product found in the inner bark of the tree Handroanthus impetiginosus, that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness inhibitor.

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