NUS1

NUS1
Identifiers
Aliases	NUS1, C6orf68, MGC:7199, NgBR, TANGO14, NUS1 dehydrodolichyl diphosphate synthase subunit, CDG1AA, MRD55, dehydrodolichyl diphosphate synthase subunit
External IDs	OMIM: 610463; MGI: 1196365; HomoloGene: 12719; GeneCards: NUS1; OMA:NUS1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	117,710,727 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	52,316,279 bp
RNA expression pattern
	Top expressed in
	endometrium; ; tibia; ; islet of Langerhans; ; skin of arm; ; cartilage tissue; ; mucosa of ileum; ; oocyte; ; mucosa of nose; ; nasal epithelium; ; cardiac muscle tissue of right atrium;
	Top expressed in
	human kidney; ; stroma of bone marrow; ; parotid gland; ; secondary oocyte; ; Epithelium of choroid plexus; ; olfactory tubercle; ; endothelial cell of lymphatic vessel; ; seminal vesicula; ; efferent ductule; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein binding; prenyltransferase activity; transferase activity, transferring alkyl or aryl (other than methyl) groups; molecular function; dehydrodolichyl diphosphate synthase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; dehydrodolichyl diphosphate synthase complex;
Biological process	cell differentiation; dolichol biosynthetic process; regulation of intracellular cholesterol transport; sterol homeostasis; multicellular organism development; protein glycosylation; angiogenesis; protein mannosylation; cholesterol homeostasis; vascular endothelial growth factor signaling pathway; positive regulation of blood vessel endothelial cell migration; positive regulation of nitric-oxide synthase activity; dolichyl diphosphate biosynthetic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	116150
	52014
	ENSG00000153989
	ENSMUSG00000023068
	Q96E22
	Q99LJ8
	NM_138459
	NM_030250
	NP_612468
	NP_084526
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear undecaprenyl pyrophosphate synthase 1 homolog (NUS1), or dehydrodolichyl diphosphate synthase complex subunit NUS1, or Nogo-B receptor (NgBR) is a protein that in humans is encoded by the NUS1 gene. Mutations within the NUS1 gene lead to a diagnosis of an NUS1 genetic disorder.