NOTCH regulated ankyrin repeat protein is a protein that in humans is encoded by the NRARP gene.
It is also found in insects, nematodes, mammals, and sea urchins.The Notch Regulated Ankyrin Repeat Protein is expressed in many tissues, including the brain, heart, colon, kidney, and lungs. It can also be found in developing body structures, such as the presomitic mesoderm, vascular endothelial cells, and neural plate. This suggests that NRARP plays an important role in tissues, including those that are still developing. In humans, the NRARP gene is located on chromosome 9, the band it is on is 9q34.3. For the strand, it is on the reverse (negative) strand. For mice, it is on chromosome 2.
Participates in the Notch signaling pathway. Acts upstream or downstream of the negative regulation of the Notch signaling pathway and the positive regulation of the standard Wnt signaling pathway.
The Notch Regulated Ankyrin Repeat Protein (NRARP) is part of a negative feedback system that helps control the Notch signaling pathway. It also plays a role in regulating the Wnt signaling pathway.. NRARP is rapidly induced by the Notch activation and plays a role in controlling the strength, duration, and downstream transcriptional output of Notch signaling. The notch and Wnt pathways both mediate important signaling processes in cells. NRARP is the positive regulator of the transcription factor LEF1, which can block some of its degradation. Additionally, there are different genes in the family that encode various amounts of the membrane receptors. The Notch intracellular domain travels to the cell nucleus, where it interacts with the recombination signal-binding protein for the immunoglobulin kappa J region (RBPJ) and other transcriptional cofactors to initiate expression of the Notch target genes. There is one that codes for a 114-amino-acid protein containing two ankyrin repeat motifs.