NPR2

NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDs	OMIM: 108961; MGI: 97372; HomoloGene: 2970; GeneCards: NPR2; OMA:NPR2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,809,732 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,651,244 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; anterior pituitary; ; canal of the cervix; ; ascending aorta; ; Descending thoracic aorta; ; body of uterus; ; stromal cell of endometrium; ; left uterine tube; ; muscle layer of sigmoid colon;
	Top expressed in
	neural layer of retina; ; soleus muscle; ; ankle; ; skin of external ear; ; extraocular muscle; ; muscle of thigh; ; median eminence; ; cumulus cell; ; spinal ganglia; ; tunica media of zone of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; nucleotide binding; hormone binding; GTP binding; lyase activity; identical protein binding; phosphorus-oxygen lyase activity; ATP binding; guanylate cyclase activity; natriuretic peptide receptor activity; peptide hormone binding; protein binding; adenylate cyclase activity; peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; guanylate cyclase complex, soluble; integral component of plasma membrane; intracellular anatomical structure;
Biological process	negative regulation of meiotic cell cycle; regulation of cardiac conduction; intracellular signal transduction; ossification; negative regulation of oocyte maturation; cyclic nucleotide biosynthetic process; regulation of blood pressure; cGMP biosynthetic process; protein phosphorylation; cellular response to granulocyte macrophage colony-stimulating factor stimulus; bone development; receptor guanylyl cyclase signaling pathway; reproductive process; positive regulation of cGMP-mediated signaling; cGMP-mediated signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4882
	230103
	ENSG00000159899
	ENSMUSG00000028469
	P20594
	Q6VVW5
	NM_000907; NM_003995; NM_001378923
	NM_173788; NM_001355466
	NP_003986; NP_001365852
	NP_776149; NP_001342395
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor B (NPR2), also known as atrionatriuretic peptide receptor B and formerly as guanylate cyclase B, is an atrial natriuretic peptide receptor which in humans is encoded by the NPR2 gene.

A mutation in the NPR2 gene can result in achondroplasia and disproportionate dwarfism with short limbs.