NOX2

CYBB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A1F
Identifiers
Aliases	CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX, cytochrome b-245 beta chain, CGDX
External IDs	OMIM: 300481; MGI: 88574; HomoloGene: 68054; GeneCards: CYBB; OMA:CYBB - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	37,813,461 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	9,354,010 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; bone marrow; ; bone marrow cell; ; synovial joint; ; blood; ; trabecular bone; ; appendix; ; lymph node; ; decidua;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; mesenteric lymph nodes; ; right lung lobe; ; spleen; ; lumbar spinal ganglion; ; tibiofemoral joint; ; calvaria; ; blood; ; ankle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	flavin adenine dinucleotide binding; superoxide-generating NAD(P)H oxidase activity; metal ion binding; voltage-gated ion channel activity; protein binding; heme binding; protein heterodimerization activity; electron transfer activity; oxidoreductase activity;
Cellular component	cytoplasm; integral component of membrane; phagocytic vesicle membrane; membrane; plasma membrane; integral component of plasma membrane; NADPH oxidase complex; perinuclear region of cytoplasm; phagocytic vesicle; Golgi apparatus; endoplasmic reticulum; soma; intracellular anatomical structure; endoplasmic reticulum membrane; rough endoplasmic reticulum; dendrite; nuclear envelope; specific granule membrane; tertiary granule membrane; perinuclear endoplasmic reticulum;
Biological process	regulation of ion transmembrane transport; ion transport; superoxide anion generation; respiratory burst; vascular endothelial growth factor receptor signaling pathway; hydrogen peroxide biosynthetic process; innate immune response; inflammatory response; superoxide metabolic process; cellular response to L-glutamine; positive regulation of angiogenesis; response to angiotensin; response to nutrient; cellular response to hypoxia; hypoxia-inducible factor-1alpha signaling pathway; cellular response to cadmium ion; cellular response to ethanol; response to aldosterone; neutrophil degranulation; cellular response to oxidative stress; electron transport chain; ion transmembrane transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response; cell redox homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	1536
	13058
	ENSG00000165168
	ENSMUSG00000015340
	P04839
	Q61093
	NM_000397
	NM_007807
	NP_000388
	NP_031833
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).