NME2

NME2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BBB, 3BBF, 1NSK, 3BBC, 1NUE
Identifiers
Aliases	NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF, NME/NM23 nucleoside diphosphate kinase 2
External IDs	OMIM: 156491; MGI: 97356; HomoloGene: 133879; GeneCards: NME2; OMA:NME2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	51,171,744 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	93,847,085 bp
RNA expression pattern
	Top expressed in
	left ovary; ; skin of abdomen; ; skin of leg; ; left coronary artery; ; canal of the cervix; ; mucosa of esophagus; ; mucosa of transverse colon; ; lactiferous gland; ; right ovary; ; body of pancreas;
	Top expressed in
	right kidney; ; epiblast; ; pancreas; ; quadriceps femoris muscle; ; morula; ; human kidney; ; islet of Langerhans; ; muscle tissue; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotide binding; protein histidine kinase activity; DNA-binding transcription factor activity; metal ion binding; kinase activity; protein binding; ATP binding; nucleoside diphosphate kinase activity; protein serine/threonine kinase activity; fatty acid binding; intermediate filament binding; enzyme binding; transcription coactivator activity; GDP binding; G-quadruplex DNA binding;
Cellular component	cytoplasm; cytosol; cell projection; focal adhesion; ruffle; extracellular exosome; nucleus; cell periphery; lamellipodium; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; intermediate filament; mitochondrial membranes; perinuclear region of cytoplasm;
Biological process	UTP biosynthetic process; peptidyl-histidine phosphorylation; nucleobase-containing small molecule interconversion; CTP biosynthetic process; regulation of transcription, DNA-templated; phosphorylation; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; negative regulation of apoptotic process; nucleotide metabolic process; nucleoside diphosphate phosphorylation; transcription, DNA-templated; cell adhesion; nucleoside triphosphate biosynthetic process; integrin-mediated signaling pathway; GTP biosynthetic process; regulation of epidermis development; positive regulation of transcription by RNA polymerase II; neutrophil degranulation; negative regulation of myeloid leukocyte differentiation; positive regulation of neuron projection development; cellular response to oxidative stress; protein autophosphorylation; protein complex oligomerization; response to growth hormone; cellular response to glucose stimulus; cellular response to fatty acid; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4831
	18103
	ENSG00000243678
	ENSMUSG00000020857
	P22392
	Q01768
	NM_002512; NM_001018137; NM_001018138; NM_001018139; NM_001198682
	NM_001077529; NM_008705
NP_001018147; NP_001018148; NP_001018149; NP_001185611; NP_002503;
	NP_001018146
	NP_001070997; NP_032731
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.