NLRP12

NLRP12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L6A, 4XHS
Identifiers
Aliases	NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2, NLR family, pyrin domain containing 12, NLR family pyrin domain containing 12
External IDs	OMIM: 609648; MGI: 2676630; HomoloGene: 16972; GeneCards: NLRP12; OMA:NLRP12 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	53,824,394 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,298,370 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; secondary oocyte; ; buccal mucosa cell; ; trabecular bone; ; bone marrow cell; ; spleen; ; appendix; ; right lung;
	Top expressed in
	granulocyte; ; liver; ; morula; ; blastocyst; ; epiblast; ; placenta; ; bone marrow; ; yolk sac; ; spleen; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; cysteine-type endopeptidase activator activity involved in apoptotic process; ATP binding; protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	dendritic cell migration; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of Toll signaling pathway; signal transduction; negative regulation of NIK/NF-kappaB signaling; negative regulation of inflammatory response; cellular response to cytokine stimulus; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; negative regulation of protein autophosphorylation; positive regulation of MHC class I biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of signal transduction; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	91662
	378425
	ENSG00000142405
	ENSMUSG00000078817
	P59046
	E9Q5R7
	NM_001277126; NM_001277129; NM_033297; NM_144687
	NM_001033431
	NP_001264055; NP_001264058; NP_653288
	NP_001028603
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.