Homeobox protein Nkx-2.5

NKX2-5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RKQ, 4S0H
Identifiers
Aliases	NKX2-5, CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3, NK2 homeobox 5
External IDs	OMIM: 600584; MGI: 97350; HomoloGene: 3230; GeneCards: NKX2-5; OMA:NKX2-5 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	173,235,311 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,063,983 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; left ventricle; ; right ventricle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; spleen; ; gonad; ; vena cava; ; body of tongue;
	Top expressed in
	atrium; ; interventricular septum; ; right ventricle; ; myocardium of atrium; ; myocardium of ventricle; ; cardiac muscles; ; endocardial cushion; ; Cardiac muscle tissue of myocardium; ; cardiac muscle tissue of left ventricle; ; tongue muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; protein homodimerization activity; serum response element binding; chromatin binding; protein binding; DNA binding; sequence-specific DNA binding; transcription coregulator activity; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; transcription regulator complex; RNA polymerase II transcription regulator complex; protein-containing complex; protein-DNA complex;
Biological process	cardiac conduction system development; apoptotic process involved in heart morphogenesis; bundle of His development; regulation of transcription by RNA polymerase II; atrioventricular node cell development; outflow tract morphogenesis; embryonic heart tube development; vasculogenesis; heart looping; atrial septum morphogenesis; positive regulation of heart contraction; proepicardium development; pulmonary myocardium development; heart contraction; ventricular cardiac muscle cell development; negative regulation of canonical Wnt signaling pathway; pharyngeal system development; atrioventricular node development; cardiac ventricle formation; regulation of transcription, DNA-templated; cardiac muscle contraction; regulation of cardiac muscle cell proliferation; heart trabecula formation; ventricular septum morphogenesis; cardiac muscle cell differentiation; Purkinje myocyte differentiation; spleen development; positive regulation of transcription, DNA-templated; development of the heart; positive regulation of neuron differentiation; positive regulation of cardioblast differentiation; septum secundum development; atrial cardiac muscle cell development; cell differentiation; adult heart development; right ventricular cardiac muscle tissue morphogenesis; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of transcription initiation from RNA polymerase II promoter; cardiac muscle cell proliferation; BMP signaling pathway; ventricular trabecula myocardium morphogenesis; outflow tract septum morphogenesis; negative regulation of cardiac muscle cell apoptotic process; thyroid gland development; canonical Wnt signaling pathway; negative regulation of transcription, DNA-templated; sarcomere organization; cardiac ventricle morphogenesis; regulation of cardiac conduction; cardiac muscle tissue development; embryonic heart tube left/right pattern formation; heart morphogenesis; cardiac muscle tissue morphogenesis; multicellular organism development; positive regulation of gene expression; positive regulation of cell population proliferation; positive regulation of sodium ion transport; negative regulation of myotube differentiation; regulation of cardiac muscle contraction; ventricular cardiac myofibril assembly; atrioventricular node cell fate commitment; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	1482
	18091
	ENSG00000183072
	ENSMUSG00000015579
	P52952
	P42582
	NM_004387; NM_001166175; NM_001166176
	NM_008700
	NP_001159647; NP_001159648; NP_004378
	NP_032726
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2-5 gene.