Neurofilament light polypeptide

NEFL
Identifiers
Aliases	NEFL, CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110, neurofilament, light polypeptide, neurofilament light, CMTDIG, neurofilament light chain
External IDs	OMIM: 162280; MGI: 97313; HomoloGene: 4487; GeneCards: NEFL; OMA:NEFL - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	24,956,721 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	68,326,544 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; pons; ; lateral nuclear group of thalamus; ; endothelial cell; ; superior vestibular nucleus; ; Brodmann area 23; ; orbitofrontal cortex; ; pars compacta; ; middle temporal gyrus; ; frontal pole;
	Top expressed in
	motor neuron; ; facial motor nucleus; ; anterior horn of spinal cord; ; deep cerebellar nuclei; ; superior cervical ganglion; ; medial vestibular nucleus; ; pontine nuclei; ; trigeminal ganglion; ; dorsal tegmental nucleus; ; substantia nigra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; structural molecule activity; structural constituent of cytoskeleton; protein C-terminus binding; protein binding; identical protein binding; protein heterodimerization activity; protein domain specific binding; phospholipase binding; structural constituent of postsynaptic intermediate filament cytoskeleton;
Cellular component	cytoplasm; cytosol; neurofilament; growth cone; myelin sheath; TSC1-TSC2 complex; axon; neuron projection; intermediate filament; axon cytoplasm; neuromuscular junction; Schaffer collateral - CA1 synapse; cholinergic synapse; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton;
Biological process	negative regulation of neuron apoptotic process; retrograde axonal transport; intermediate filament organization; response to sodium arsenite; neuron projection morphogenesis; protein polymerization; intermediate filament bundle assembly; neuromuscular process controlling balance; neurofilament bundle assembly; response to corticosterone; response to peptide hormone; response to organic substance; positive regulation of axonogenesis; MAPK cascade; anterograde axonal transport; axonal transport of mitochondrion; regulation of axon diameter; peripheral nervous system axon regeneration; locomotion; response to acrylamide; spinal cord development; cerebral cortex development; intermediate filament polymerization or depolymerization; neurofilament cytoskeleton organization; hippocampus development; response to toxic substance; microtubule cytoskeleton organization; axon development; synapse maturation; postsynaptic intermediate filament cytoskeleton organization; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4747
	18039
	ENSG00000277586
	ENSMUSG00000022055
	P07196
	P08551
	NM_006158
	NM_010910
	NP_006149
	NP_035040
	Wikidata
View/Edit Human	View/Edit Mouse

Neurofilament light polypeptide is a protein that in humans is encoded by the NEFL gene.