Myricanol

Myricanol
Identifiers
	IUPAC name (9R)-16,17-dimethoxytricyclo[12.3.1.12,6]nonadeca-1(17),2,4,6(19),14(18),15-hexaene-3,9,15-triol;
CAS Number	33606-81-4;
PubChem CID	161779;
ChemSpider	142086;
ChEMBL	ChEMBL2152654;
CompTox Dashboard (EPA)	DTXSID10955239 ;
Chemical and physical data
Formula	C21H26O5
Molar mass	358.434 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C2C=C(CCCC[C@H](CCC3=CC2=C(C=C3)O)O)C(=C1OC)O;
	InChI InChI=1S/C21H26O5/c1-25-20-17-12-14(19(24)21(20)26-2)5-3-4-6-15(22)9-7-13-8-10-18(23)16(17)11-13/h8,10-12,15,22-24H,3-7,9H2,1-2H3/t15-/m1/s1; Key:SBGBAZQAEOWGFT-OAHLLOKOSA-N;

Myricanol, is a natural product which acts as an activator of the enzymes nicotinamide phosphoribosyltransferase (NAMPT) and SIRT1, along with various other activities. It is derived from the ayurvedic medicinal plant Myrica nagi and other related species along with other similar compounds such as myricetin.

It has hepatoprotective, reno-protective neuroprotective and anti-cancer properties in experimental models, and lowers levels of microtubule-associated protein tau.