Myotubularin
| Myotubularin-related | |||||||
|---|---|---|---|---|---|---|---|
Structure of a phosphoinositide phosphatase. | |||||||
| Identifiers | |||||||
| Symbol | Myotub-related | ||||||
| Pfam | PF06602 | ||||||
| InterPro | IPR010569 | ||||||
| SCOP2 | 1m7r / SCOPe / SUPFAM | ||||||
| OPM superfamily | 130 | ||||||
| OPM protein | 1zvr | ||||||
| |||||||
Myotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.