Mianserin

Mianserin
Clinical data
Trade names	Tolvon, others
Other names	Mianserin hydrochloride; Org GB 94
Pregnancy; category	AU: B2; ;
Routes of; administration	By mouth
ATC code	N06AX03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	20–30%
Protein binding	95%
Metabolism	Liver (CYP2D6; via aromatic hydroxylation, N-oxidation, N-demethylation)
Elimination half-life	21–61 hours
Excretion	Urine: 4–7%; Feces: 14–28%
Identifiers
	IUPAC name (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine;
CAS Number	24219-97-4 ; 21535-47-7 (hydrochloride); 51152-88-6 ((S)-isomer);
PubChem CID	4184;
IUPHAR/BPS	135;
DrugBank	DB06148 ;
ChemSpider	4040 ;
UNII	250PJI13LM;
KEGG	D08216 ;
ChEBI	CHEBI:51137 ;
ChEMBL	ChEMBL6437 ;
CompTox Dashboard (EPA)	DTXSID6023317 ;
ECHA InfoCard	100.041.884
Chemical and physical data
Formula	C18H20N2
Molar mass	264.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c42c(N3C(c1ccccc1C2)CN(C)CC3)cccc4;
	InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 ; Key:UEQUQVLFIPOEMF-UHFFFAOYSA-N ;
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Mianserin, sold as Tolvon and other brand names, is an atypical antidepressant used primarily for treating depression in Europe and other countries. It is a tetracyclic antidepressant (TeCA) and is closely related to mirtazapine in terms of chemical structure, actions, and effects, although mianserin has greater noradrenergic activity and less 5-HT3 receptor antagonism.