Mepolizumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | IL-5 |
| Clinical data | |
| Trade names | Nucala |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a615058 |
| License data |
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| Routes of administration | Subcutaneous injection |
| ATC code | |
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| Pharmacokinetic data | |
| Bioavailability | 80% (estimate) |
| Protein binding | None |
| Metabolism | Proteolytic enzymes |
| Elimination half-life | 20 (16–22) days |
| Identifiers | |
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| DrugBank | |
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| Chemical and physical data | |
| Molar mass | 149 kDa |
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome.
The most common side effects include headache, injection site reactions, and back pain.