Megestrol

Megestrol
Clinical data
ATC code	G03AC05 ;
Identifiers
	IUPAC name 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione;
CAS Number	3562-63-8 ;
PubChem CID	1909019090;
ChemSpider	18023 ;
UNII	EA6LD1M70M;
ChEBI	CHEBI:6722 ;
CompTox Dashboard (EPA)	DTXSID001009330 ;
ECHA InfoCard	100.020.571
Chemical and physical data
Formula	C22H30O3
Molar mass	342.479 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4\C=C3\C(=C/[C@@H]1[C@H](CC[C@@]2([C@@](O)(C(=O)C)CC[C@@H]12)C)[C@@]3(C)CC4)C;
	InChI InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1 ; Key:VXIMPSPISRVBPZ-NWUMPJBXSA-N ;
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Megestrol (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name) is a progestin of the 17α-hydroxyprogesterone group which was, until recently, never marketed or used clinically. It is now used for treatments of disease-related weight loss, endometrial cancer, and breast cancer. Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.