Medrysone

Medrysone
Clinical data
Trade names	HMS, Medrocort, others
Other names	NSC-63278; Hydroxymethylprogesterone; Methylhydroxyprogesterone; Hydroxymesterone; 6α-Methyl-11β-hydroxyprogesterone; 6α-Methyl-11β-hydroxypregn-4-ene-3,20-dione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a606003
Routes of; administration	Eye drops
ATC code	S01BA08 (WHO) ;
Legal status
Legal status	US: Discontinued;
Identifiers
	IUPAC name (6S,8S,9S,10R,11S,13R,14S,17S)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,; 11,12,14,15,16,17- dodecahydrocyclopenta[a] phenanthren-3-one;
CAS Number	2668-66-8 ;
PubChem CID	247839;
IUPHAR/BPS	7086;
DrugBank	DB00253 ;
ChemSpider	216968 ;
UNII	D2UFC189XF;
KEGG	D02289 ;
ChEMBL	ChEMBL1201173 ;
CompTox Dashboard (EPA)	DTXSID6045371 ;
ECHA InfoCard	100.018.371
Chemical and physical data
Formula	C22H32O3
Molar mass	344.495 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C;
	InChI InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 ; Key:GZENKSODFLBBHQ-ILSZZQPISA-N ;
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Medrysone (INN, USAN; brand names HMS, Medrocort, others; former developmental code NSC-63278; also known as hydroxymethylprogesterone, methylhydroxyprogesterone, hydroxymesterone, 6α-methyl-11β-hydroxyprogesterone, or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione) is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases. It has been discontinued in the United States. Although it is very similar in structure to progesterone, neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.