Medical cannabis research

Medical cannabis research refers to scientific investigations into the therapeutic use of cannabis and its derivatives.

The earliest systematic studies on the physiological effects of cannabis-derived chemicals were conducted in the 1920s. Research activity in this field remained relatively low and stable until 1966, when the number of publications increased tenfold over the following decade. Following the adoption of the Convention on Psychotropic Substances in 1971, the volume of research publications declined, a trend that persisted until approximately 1987. Since that time, cannabis research has steadily increased.

There is no clear inflection point corresponding to 2013, when Uruguay became the first country to fully regulate its cannabis market, encompassing production, distribution, and consumption. Subsequently, many countries implemented policies governing medical cannabis research, which vary significantly between jurisdictions.

There is mixed and inconclusive evidence on the benefits of cannabis-based medicines, frequent mild adverse effects, and generally low-to-moderate quality of evidence.

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