mTOR

MTOR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Identifiers
Aliases	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
External IDs	OMIM: 601231; MGI: 1928394; HomoloGene: 3637; GeneCards: MTOR; OMA:MTOR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,262,551 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,642,140 bp
RNA expression pattern
	Top expressed in
	gonad; ; right hemisphere of cerebellum; ; left testis; ; right testis; ; gastrocnemius muscle; ; right frontal lobe; ; muscle of thigh; ; testicle; ; ventricular zone; ; apex of heart;
	Top expressed in
	spermatid; ; spermatocyte; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; genital tubercle; ; primary visual cortex; ; muscle of thigh; ; ventricular zone; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; TFIIIC-class transcription factor complex binding; kinase activity; ATP binding; protein serine/threonine kinase activity; transferase activity; ribosome binding; protein binding; protein kinase binding; nucleotide binding; phosphoprotein binding; protein kinase activity; protein-containing complex binding; identical protein binding; translation regulator activity;
Cellular component	cytoplasm; cytosol; phosphatidylinositol 3-kinase complex; membrane; mitochondrion; TORC1 complex; organelle membrane; protein-containing complex; mitochondrial outer membrane; endoplasmic reticulum; TORC2 complex; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; soma; PML body; endoplasmic reticulum membrane; Golgi membrane; lysosomal membrane; dendrite; endomembrane system; nucleus; lysosome; glutamatergic synapse; postsynaptic cytosol;
Biological process	germ cell development; positive regulation of protein phosphorylation; response to amino acid; positive regulation of lipid biosynthetic process; positive regulation of actin filament polymerization; positive regulation of skeletal muscle hypertrophy; positive regulation of granulosa cell proliferation; regulation of carbohydrate utilization; post-embryonic development; positive regulation of dendritic spine development; positive regulation of translation; positive regulation of eating behavior; protein phosphorylation; mRNA stabilization; cell projection organization; regulation of glycogen biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of neuron maturation; positive regulation of glial cell proliferation; cellular response to hypoxia; negative regulation of cell size; response to cocaine; positive regulation of protein kinase B signaling; cardiac muscle contraction; maternal process involved in female pregnancy; ruffle organization; regulation of GTPase activity; cardiac muscle cell development; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of membrane permeability; response to insulin; regulation of myelination; regulation of fatty acid beta-oxidation; regulation of osteoclast differentiation; positive regulation of cholangiocyte proliferation; regulation of protein kinase B signaling; spinal cord development; positive regulation of peptidyl-tyrosine phosphorylation; social behavior; protein autophosphorylation; negative regulation of cholangiocyte apoptotic process; regulation of brown fat cell differentiation; regulation of protein kinase activity; negative regulation of protein phosphorylation; positive regulation of oligodendrocyte differentiation; regulation of carbohydrate metabolic process; regulation of actin cytoskeleton organization; voluntary musculoskeletal movement; phosphorylation; multicellular organism growth; negative regulation of muscle atrophy; wound healing; positive regulation of neurogenesis; response to morphine; positive regulation of sensory perception of pain; protein catabolic process; 'de novo' pyrimidine nucleobase biosynthetic process; cellular response to nutrient levels; energy reserve metabolic process; peptidyl-threonine phosphorylation; positive regulation of transcription by RNA polymerase III; positive regulation of smooth muscle cell proliferation; visual learning; positive regulation of myotube differentiation; positive regulation of cell death; positive regulation of endothelial cell proliferation; negative regulation of iodide transmembrane transport; cardiac muscle tissue development; positive regulation of nitric oxide biosynthetic process; regulation of response to food; heart morphogenesis; positive regulation of neuron death; cardiac cell development; negative regulation of protein ubiquitination; brain development; positive regulation of gene expression; long-term memory; heart valve morphogenesis; peptidyl-serine phosphorylation; positive regulation of neuron projection development; regulation of cellular response to heat; positive regulation of lamellipodium assembly; positive regulation of stress fiber assembly; signal transduction; regulation of protein phosphorylation; negative regulation of macroautophagy; anoikis; TOR signaling; DNA repair; regulation of cell size; negative regulation of autophagy; positive regulation of epithelial to mesenchymal transition; regulation of macroautophagy; cellular response to amino acid starvation; positive regulation of keratinocyte migration; cellular response to amino acid stimulus; cellular response to leucine; positive regulation of wound healing, spreading of epidermal cells; cellular response to leucine starvation; cellular response to starvation; TORC1 signaling; growth; regulation of cell growth; response to nutrient; activation of protein kinase B activity; T-helper 1 cell lineage commitment; response to activity; positive regulation of phosphoprotein phosphatase activity; negative regulation of calcineurin-NFAT signaling cascade; regulation of translation at synapse, modulating synaptic transmission; positive regulation of cytoplasmic translational initiation; response to nutrient levels;
	Sources:Amigo / QuickGO
Orthologs
	2475
	56717
	ENSG00000198793
	ENSMUSG00000028991
	P42345
	Q9JLN9
	NM_004958; NM_001386500; NM_001386501
	NM_020009
	NP_004949
	NP_064393
	Wikidata
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The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is evolutionarily conserved across eukaryotes. It also promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.