Major League Sixes
| Sport | Lacrosse Sixes |
|---|---|
| First season | 2024 |
| Organising body | Lacrosse Australia |
| Divisions | Women's and Men's |
| No. of teams | 5 each |
| Country | Australia |
| Most recent champions | Brisbane Salties (women) Melbourne Makos (men) |
| Official website | majorleaguesixes.au |
Major League Sixes is an annual elite lacrosse tournament held in Australia, played to lacrosse sixes rules — the format that will be played at the 2028 Summer Olympics — and bringing fast-paced, dynamic lacrosse to the Australian lacrosse community.
Launched in 2024, Major League Sixes marked a major shift for national lacrosse competition in Australia, with a new franchise-based draft format consisting of five even teams for both women's and men's divisions, representing major cities around the country. This was a departure from the traditional state-based representative team format used in national field and box lacrosse championships, which historically have been dominated by the traditional Australian lacrosse heartlands of Victoria, South Australia and Western Australia.