Bolivian hemorrhagic fever

Bolivian hemorrhagic fever
Other namesBlack typhus, ordog fever
SpecialtyInfectious disease
SymptomsFever, malaise, bleeding
Usual onset3–21 Days
CausesMachupo Virus
Risk factorsExposure to the Large Vesper Mouse
TreatmentSupportive care
FrequencyRare, no cases since 2008
Deaths20%–41% fatality rate

Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever, is a hemorrhagic fever and zoonotic infectious disease endemic to Bolivia after infection by Machupo virus (MACV). The virus is spread primarily by the large vesper mouse (Calomys callosus).

BHF was first recognized in 1959 during the first reported outbreak near the city of San Joaquin in the Beni district of northeast Bolivia. Symptoms include fever, malaise, bleeding, and in some cases, death. The mortality rate is estimated at about 20% but during early outbreaks has been as high as 41%.

The most recent cases of Bolivian hemorrhagic fever occurred in February 2008. Over 200 suspected cases of BHF were reported.