MYO18A

MYO18A
Identifiers
Aliases	MYO18A, MYSPDZ, SPR210, myosin XVIIIA, MAJN, SP-R210
External IDs	OMIM: 610067; MGI: 2667185; HomoloGene: 7977; GeneCards: MYO18A; OMA:MYO18A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	29,180,398 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,865,980 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; apex of heart; ; muscle of thigh; ; sural nerve; ; right auricle of heart; ; left ventricle; ; corpus callosum; ; right lobe of liver; ; epithelium of colon;
	Top expressed in
	muscle of thigh; ; esophagus; ; lip; ; triceps brachii muscle; ; ankle; ; right ventricle; ; temporal muscle; ; skeletal muscle tissue; ; intestinal villus; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ADP binding; actin filament binding; ATPase activity; protein binding; ATP binding; RNA binding;
Cellular component	cytoplasm; membrane; trans-Golgi network; actomyosin; cytoskeleton; myosin complex; endoplasmic reticulum-Golgi intermediate compartment; Golgi membrane; Golgi apparatus; cell surface;
Biological process	Golgi organization; Golgi vesicle budding; actomyosin structure organization; DNA metabolic process; asymmetric Golgi ribbon formation; negative regulation of apoptotic process; positive regulation of protein secretion; cell migration; Golgi ribbon formation; regulation of macrophage activation; positive regulation of opsonization;
	Sources:Amigo / QuickGO
Orthologs
	399687
	360013
	ENSG00000196535
	ENSMUSG00000000631
	Q92614
	Q9JMH9
NM_001346765; NM_001346766; NM_001346767; NM_001346768; NM_078471;
	NM_203318
	NM_001291212; NM_001291213; NM_001291214; NM_001291215; NM_011586
NP_001333694; NP_001333695; NP_001333696; NP_001333697; NP_510880;
	NP_976063
	NP_001278141; NP_001278142; NP_001278143; NP_001278144; NP_035716
	Wikidata
View/Edit Human	View/Edit Mouse

MYO18A is a large unconventional myosin protein encoded in humans by the MYO18A gene. Unlike classical myosins that are involved in muscle contraction, unconventional myosins serve a variety of functions in non-muscle cells, such that include cargo transport, cytoskeletal regulation, membrane dynamics, and signaling. MYO18A is distinguished from other myosins by the presence of a unique amino-terminal PDZ domain, extensive coiled-coil regions, and an alternative myosin motor-like domain that lacks functional ATPase activity. Across various studies, this protein has appeared under multiple names related to function, including myosin containing a PDZ domain (MYSPDZ), Molecule Associated with JAK3 N-terminus (MAJN), TGFB1-induced anti-apoptotic factor 1 (TIAF1), surfactant protein receptor SP-R210. These alternative names reflect the array of biological contexts in which MYO18A has been studied, ranging from immune cell signaling to surfactant protein receptor biology in the lung.

MYO18A is ubiquitously expressed and participates in key structural and regulatory processes including Golgi morphology, actin cytoskeletal organization, vesicle trafficking, innate immune receptor regulation, and pathogen clearance. Although structurally similar to a myosin motor protein, current biochemical evidence suggests that MYO18A may act as primarily as a scaffolding protein that cooperates with actin-binding factors, kinases, and membrane associated adaptors to coordinate intricate cellular behaviors.