MTRR (gene)

MTRR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QTL, 2QTZ
Identifiers
Aliases	MTRR, MSR, cblE, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
External IDs	OMIM: 602568; MGI: 1891037; HomoloGene: 11419; GeneCards: MTRR; OMA:MTRR - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	7,906,025 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	68,730,268 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic ductal cell; ; Epithelium of choroid plexus; ; upper lobe of left lung; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; kidney tubule; ; right ventricle; ; monocyte; ; rectum;
	Top expressed in
	renal corpuscle; ; yolk sac; ; muscle of thigh; ; medullary collecting duct; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; ureter; ; blastocyst; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	FMN binding; NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding; FAD binding; protein binding; NADP binding; NADPH binding; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor; oxidoreductase activity; (Methionine synthase) reductase; [methionine synthase reductase activity];
Cellular component	cytosol; cytoplasm;
Biological process	cobalamin metabolic process; cellular amino acid biosynthetic process; methionine biosynthetic process; DNA methylation; methionine metabolic process; homocysteine catabolic process; folic acid metabolic process; negative regulation of cystathionine beta-synthase activity; S-adenosylmethionine cycle; homocysteine metabolic process; sulfur amino acid metabolic process; methylation;
	Sources:Amigo / QuickGO
Orthologs
	4552
	210009
	ENSG00000124275
	ENSMUSG00000034617
	Q9UBK8
	Q8C1A3
	NM_002454; NM_024010
	NM_172480; NM_001308475
	NP_002445; NP_076915; NP_001351369; NP_001351370; NP_001351371
	NP_001295404; NP_766068
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine synthase reductase, also known as MSR, is an enzyme in humans that is encoded by the MTRR gene. It functions as the obligate reductase for methionine synthase and restores its cofactor to an active state allowing it to sustain folate and methionine metabolosis.