MMP3

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Stromelysin 1
Stromelysin 1
Identifiers
EC no.	3.4.24.17
CAS no.	79955-99-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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NCBI	proteins

MMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B3D, 1B8Y, 1BIW, 1BM6, 1BQO, 1C3I, 1C8T, 1CAQ, 1CIZ, 1CQR, 1D5J, 1D7X, 1D8F, 1D8M, 1G05, 1G49, 1G4K, 1HFS, 1HY7, 1OO9, 1QIA, 1QIC, 1SLM, 1SLN, 1UEA, 1UMS, 1UMT, 1USN, 2D1O, 2JNP, 2JT5, 2JT6, 2SRT, 2USN, 3OHL, 3OHO, 3USN, 4DPE, 4G9L, 4JA1
Identifiers
Aliases	MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1, matrix metallopeptidase 3
External IDs	OMIM: 185250; MGI: 97010; HomoloGene: 20545; GeneCards: MMP3; OMA:MMP3 - orthologs
EC number	3.4.24.17
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,843,609 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,455,975 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; cartilage tissue; ; pericardium; ; tendon of biceps brachii; ; synovial joint; ; synovial membrane of articular capsule of synovial joint; ; minor salivary glands; ; islet of Langerhans; ; stromal cell of endometrium; ; testicle;
	Top expressed in
	lactiferous gland; ; ankle joint; ; conjunctival fornix; ; skin of external ear; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; tunica media of zone of aorta; ; endothelial cell of lymphatic vessel; ; right lung lobe; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; endopeptidase activity; metalloendopeptidase activity; protein binding; hydrolase activity; metal ion binding; serine-type endopeptidase activity; metallopeptidase activity;
Cellular component	extracellular matrix; extracellular region; extracellular space;
Biological process	collagen catabolic process; cellular response to nitric oxide; negative regulation of hydrogen peroxide metabolic process; extracellular matrix disassembly; proteolysis; positive regulation of protein oligomerization; positive regulation of oxidative stress-induced cell death; cytokine-mediated signaling pathway; response to hypoxia; regulation of cell migration; regulation of neuroinflammatory response; extracellular matrix organization; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4314
	17392
	ENSG00000149968
	ENSMUSG00000043613
	P08254
	P28862
	NM_002422
	NM_010809
	NP_002413
	NP_034939
	Wikidata
View/Edit Human	View/Edit Mouse

Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-3 has an estimated molecular weight of 54 kDa.